Endoxifen Datasheet DC Chemicals
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Cat.No DC8265
Name Endoxifen

Chemical Properties

CAS 112093-28-4
Formula C25H27NO2
MW 373.48700
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：112093-28-4
Product Name：Phenol,4-[(1Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
Synonyms：Phenol,4-[(1Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-;Endoxifen;4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol;Endoxifen (Z-isomer);Endoxifen NEW;4-Hydroxy-N-desmethyltamoxifen;4OHNDtam;UNII-46AF8680RC;Z-Endoxifen;4-[(1Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol;N-Desmethyl-4-hydroxytamoxifen
EINEC:
Molecular Formula：C25H27NO2
Molecular Weight：373.48700
Target: hERG Potassium Channel IC50 value: 1.6 μM [1]
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Chae YJ, et al. Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr 5;752:1-7. [2]. Wu X, et al. Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 2011 Mar 10;13(2):R27.
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