GMB-475 Datasheet DC Chemicals

Description	GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1].
Cat.No	DC31014
Name	GMB-475

Chemical Properties

CAS	2490599-18-1
Formula	C43H46F3N7O7S
MW	861.93
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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