GNE-9278 Datasheet DC Chemicals
Description GNE-9278 is a potent and selective NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Mutation of a single residue near the Lurcher motif on GluN1 M3 can convert GNE-9278 modulation from positive to negative, and replacing three AMPAR pre-M1 residues with corresponding NMDAR residues can confer GNE-9278 sensitivity to AMPARs. Modulation by GNE-9278 is state-dependent and significantly alters extracellular domain pharmacology.
Cat.No DC33553
Name GNE-9278

Chemical Properties

CAS 901230-11-3
Formula C21H27N5O3S
MW 429.539
Storage

References

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