CID 139600315(GNF-4877) Datasheet DC Chemicals

Description	GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells)[1].
Cat.No	DC39204
Name	CID 139600315(GNF-4877)

Chemical Properties

CAS	2041073-22-5
Formula	C25H27FN6O4
MW	494.518088579178
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Shen W, et al. Inhibition of DYRK1A and GSK3β induces human β-cell proliferation. Nat Commun. 2015 Oct 26;6:8372.

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