GR 113808 Datasheet DC Chemicals
Target Home > Products > Featured products
Cat.No DC28147
Name GR 113808

Chemical Properties

CAS 144625-51-4
Formula C19H27N3O4S
MW 393.500383615494
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：144625-51-4
Product Name：1H-Indole-3-carboxylicacid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester
Synonyms：1H-Indole-3-carboxylicacid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester;[1-[2-(methanesulfonamido)ethyl]piperidin-4-yl]methyl 1-methylindole-3-carboxylate;1H-Indole-3-carboxylicacid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methy...;GR 113808;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID,[1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;Clocinnamox mesylate
EINEC:
Molecular Formula：C19H27N3O4S
Molecular Weight：393.500383615494
Target:
In Vivo GR113808 (intraperitoneal injection; 1 mg/kg; 5-7 days starting 24 h after induction of colitis) shows a significant increase in the disease activity index (DAI),which includes evaluation of weight loss, stool consistency, and presence of fecal blood[2]. Animal Model: Mice[1] Dosage: 1 mg/Kg Administration: Intraperitoneal injection; 1 mg/Kg; 5-7 days starting 24 h after induction of colitis Result: Blocked protective effects of tegaserod after induction of colitis.
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Gale JD, et al. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.Br J Pharmacol. 1994 Jan;111(1):332-8. [2]. Spohn SN, et al.Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.Gastroenterology. 2016 Nov;151(5):933-944.e3.
Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
Tel: +86-21-58447131
Fax: +86-21-61642470

Email:
sales@dcchemicals.com
order@dcchemicals.com

Website:
www.dcchemicals.com