GSK-2018682 Datasheet DC Chemicals
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Cat.No DC10561
Name GSK-2018682

Chemical Properties

CAS 1034688-30-6
Formula C22H21CLN4O4
MW 440.884
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1034688-30-6
Product Name：
Synonyms：GSK-2018682,GSK 2018682，GSK2018682
EINECS:
Molecular Formula：C22H21ClN4O4
Molecular Weight：440.884
Target: pEC50: 7.7 (S1P1 receptor), 7.2 (S1P5 receptor)[1]
In Vivo
In Vitro GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Xu J, et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin Pharmacol Drug Dev. 2014 May;3(3):170-8.
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