GSK-J4 hydrochloride Datasheet DC Chemicals
Description GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable prodrug of GSK-J1.
Cat.No DC28982
Name GSK-J4 hydrochloride

Chemical Properties

CAS 1797983-09-5
Formula C24H28CLN5O2
MW 453.96
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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