GSK2798745 Datasheet DC Chemicals

Description	GSK2798745 is an inhibitor of the transient receptor potential vanilloid 4 (TRPV4) with IC50 of 1.8nM.
Cat.No	DC26197
Name	GSK2798745

Chemical Properties

CAS	1419609-94-1
Formula	C25H28N6O3
MW	460.528224945068
Storage	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

References

[1]. Goyal N, et al. Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects. Am J Cardiovasc Drugs. 2019 Jun;19(3):335-342. [2]. Brooks CA, et al. Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4). ACS Med Chem Lett. 2019 Jul 15;10(8):1228-1233.

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