GSK-25 Datasheet DC Chemicals

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Cat.No	DC8520
Name	GSK-25

Chemical Properties

CAS	874119-56-9
Formula	C24H16CL2F2N6O
MW	513.32
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:	ROCK1:7 nM (IC50) RSK1:398 nM (IC50) p70S6K:1000 nM (IC50)
In Vivo
In Vitro	GSK-25 (Rat aorta IC50=256 nM) is profiled in a spontaneously hypertensive rat (SHR) model of hypertension. At 30 mg/kg (p.o.), GSK-25 induces a 25 mmHg (t=3 hours) drop in blood pressure[1]. GSK-25 has promising oral bioavailability (49% in male Sprague-Dawley rats and 19% in monkey), good half-life (1.8 hours in rat and 2.2 hours in monkey)[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Sehon CA, et al. Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases. J Med Chem. 2008 Nov 13;51(21):6631-4.

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