2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：2387821-46-5 Product Name：Urea, N -(3-chlorophenyl)-N ′-(6-cyano-2-benzothiazolyl)- (ACI) Synonyms：HB007,HB-007,HB 007 EINECS: Molecular Formula：C15H9ClN4OS Molecular Weight：328.78
Target:
SUMO1[1]
In Vivo
HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1].
In Vitro
HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1]. HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Bellail AC, et, al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Sci Transl Med. 2021 Oct 13;13(615):eabh1486.
[2]. BELLAIL A, et, al. Compositions and methods for treating cancer. WO2019217509A1.
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