HS014 Datasheet DC Chemicals
Target Home > Products > Featured products
Cat.No DC41671
Name HS014

Chemical Properties

CAS 207678-81-7
Formula C71H94N20O17S2
MW 1563.76000
Storage Please store the product under the recommended conditions in the Certificate of Analysis.

Biological activity

Description CAS NO.：207678-81-7
Product Name：L-a-Asparagine, N-acetyl-L-cysteinyl-L-a-glutamyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-,cyclic (1®8)-disulfide
Synonyms：Acetyl-(Cys??00D-2-Nal??00Cys??)-β-MSH(11-22)amide;Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide;HS 014;L-a-Asparagine, N-acetyl-L-cysteinyl-L-a-glutamyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arg...;L-a-Asparagine, N-acetyl-L-cysteinyl-L-a-glutamyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cyste;L-a-Asparagine, N-acetyl-L-cysteinyl-L-a-glutamyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-,cyclic (1®AC-CYS-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2;M.W. 1563.77 C71H94N20O17S2;mc4receptor antagonist
EINEC:
Molecular Formula：C71H94N20O17S2
Molecular Weight：1563.76000
Target:
In Vivo The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively[2]. Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate[4].
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Schiöth HB,et al. Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol. 1998;124(1):75-82. [2]. Ercil NE, et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice. Psychopharmacology (Berl). 2005;180(2):279-285. [3]. Kask A, et al. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem Biophys Res Commun. 1998;245(1):90-93.
Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
Tel: +86-21-58447131
Fax: +86-21-61642470

Email:
sales@dcchemicals.com
order@dcchemicals.com

Website:
www.dcchemicals.com