Hydroxy desmethyl Bosentan Datasheet DC Chemicals

Description	Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension.
Cat.No	DC28843
Name	Hydroxy desmethyl Bosentan

Chemical Properties

CAS	253688-62-9
Formula	C26H27N5O7S
MW	553.59
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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