IACS-13909 Datasheet DC Chemicals

Description	IACS-13909 is a specific and potent allosteric inhibitor of SHP2 that suppresses the signaling of RTK/MAPK pathway and overcomes multiple mechanisms underlying osimertinib resistance. IACS-13909 potently impedes the proliferation of tumors with a broad spectrum of RTKs as the oncogenic driver. Importantly, in NSCLC models with acquired resistance to osimertinib, IACS-13909 administered as a single agent or in combination with osimertinib potently reduces tumor cell proliferation in vitro and in vivo. Together, our findings provide preclinical evidence for using a SHP2 inhibitor as a therapeutic strategy in acquired EGFR inhibitor-resistant NSCLC.
Cat.No	DC39701
Name	IACS-13909

Chemical Properties

CAS	2160546-07-4
Formula	C17H18CL2N6
MW	377.27
Storage	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

References

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