Infliximab is a tumor necrosis factor TNF-α blocker and a chimeric monoclonal IgG1 antibody and it is used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and severe or disabling plaque psoriasis.
Cat.No
A012
Name
Infliximab
Chemical Properties
CAS
170277-31-3
Synonyms
Immunoglobulin G,anti-(human tumor necrosis factor) (human-mouse monoclonal cA2 heavy chain),disulfide with human-mouse monoclonal cA2 light chain, dimer;Immunoglobulin G,anti-(human tumor necrosis factor) (human-mouse monoclonal cA2 heavy chain),d...;Immunoglobulin G,anti-(human tumor necrosis factor) (human-mouse monoclonal cA2 heavy chain),disulfide with human-mouse monoc;INFLIXIMAB;Avakine;CT-P 13;Remicade;Unii-B72hh48flu
pH value
Corresponds to reference standard： PASS
Non-reduced CE-SDS
98.5%
SEC-HPLC
99.4%
Isoelectric Point
Corresponds to reference standard:PASS
Bacterial Endotoxins Test
＜1 EU/ml
Residual Proteins of Host Cell
Exogenous Residual DNA
1 pg/mg
Residual protein A
＜1 ng/mg
Biological Activity
Compared with standard, the range of biological activity is 113%
Osmolality
Corresponds to reference standard: PASS
Peptide mapping
Corresponds to reference standard: PASS
N-terminal sequence
Corresponds to reference standard:PASS
References
[1]. Lucia A Méndez-García, et al. Infliximab ameliorates tumor necrosis factor-alpha-induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro. Scand J Immunol. 2018 Nov;88(5):e12716.
[2]. Isamu Yamakawa, et al. Inactivation of TNF-α ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E844-52.
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