Irigenin Datasheet DC Chemicals
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Cat.No DC23051
Name Irigenin

Chemical Properties

CAS 548-76-5
Formula C18H16O8
MW 360.3148
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：548-76-5
Product Name：Irigenin
Synonyms：4H-1-Benzopyran-4-one,5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-;5,7-Dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one;5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4-benzopyrone;5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one;irigenin;5,7,3'-trihydroxy-6,4',5'-trimethoxyisoflavone;7,5,3'-Trihydroxy-6,4',5'-trimethoxyisoflavon;EINECS 208-958-3;6O4NX37350;5,7,3'-Trimethoxy-6,4',5'-trimethoxyisoflavone;9569AF;LMPK12050417;AK554317;C17957;5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-me
EINEC:208-958-3
Molecular Formula：C18H16O8
Molecular Weight：360.3148
Target:
In Vivo
In Vitro Irigenin specifically targets α9β1 and α4β1 integrin binding sites on Extra Domain A (EDA) comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop. Irigenin binds to the C-C loop of EDA, thereby blocking its interaction with integrins on the cell surface and thus abrogating subsequent Epithelial-Mesenchymal transition[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Amin A, et al. Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells. Sci Rep. 2016 Nov 16;6:37151. [2]. Xu Y, et al. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Biochem Biophys Res Commun. 2018 Feb 12;496(3):998-1005.
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