Ivermectin B1a Datasheet DC Chemicals
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Cat.No DC40370
Name Ivermectin B1a

Chemical Properties

CAS 71827-03-7
Formula C48H74O14
MW 875.09
Storage Powder-20°C3 yearsIn solvent-80°C6 months-20°C1 month

Biological activity

Description CAS NO.：71827-03-7
Product Name：Ivermectin
Synonyms：Avermectin A1a, 5-O-demethyl-22,23-dihydro-;Ivermectin B1a;22,23-Dihydroavermectin B(1)a;22,23-Dihydro-5-O-demethylavermectin A1a;22,23-Dihydroavermectin B1a;BRN 4643153;Dihydroavermectin B1a;UNII-91Y2202OUW;Avermectin A1a, 22,23-dihydro-5-O-demethyl-;(2aE,4E,5'S,6S,6'R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl (4xi)-2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-threo-hexopyranoside;(2aE,4E,5'S,6S,6'R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][
EINEC:
Molecular Formula：C48H74O14
Molecular Weight：875.0928
Target:
In Vivo
In Vitro Ivermectin belongs to the macrocyclic lactone class of avermectins and consists of a mixture of two homologous compounds, ivermectin B1a (not less than 80%) and ivermectin B1b (not more than 20%). Ivermectin B1a, the major component of Ivermectin, is inactive at a concentration of 0.3 μg/ml, whereas in the case of the minor component, ivermectin B1b, the same concentration produces 100% mortality of snails[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Naftale Kat, et al. Ivermectin Efficacy Against Biomphalaria, Intermediate Host Snail Vectors of Schistosomiasis. J Antibiot (Tokyo). 2017 May;70(5):680-684. [2]. Khan Sharun, et al. Ivermectin, a New Candidate Therapeutic Against SARS-CoV-2/COVID-19. Ann Clin Microbiol Antimicrob. 2020 May 30;19(1):23.
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