JH295 Datasheet DC Chemicals

Description	JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint.
Cat.No	DC40234
Name	JH295

Chemical Properties

CAS	1311143-71-1
Formula	C18H16N4O2
MW	320.35
Storage	-20°C, stored under nitrogen*The compound is unstable in solutions, freshly prepared is recommended.

References

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