Kribb11 Datasheet DC Chemicals
Description KRIBB11 is a Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM).
Cat.No DC9963
Name Kribb11

Chemical Properties

CAS 342639-96-7
Formula C13H12N6O2
MW 284.2734
Storage 4°C for 1 year, -20°C for more than 2 years

References

[1]. Yoon YJ, et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem. 2011 Jan 21;286(3):1737-47. [2]. Samarasinghe B, et al. Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem Pharmacol. 2014 Feb 1;87(3):445-55. Chemical & Physical Properties
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