K-Ras-IN-1 Datasheet DC Chemicals

Description	K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.
Cat.No	DC9906
Name	K-Ras-IN-1

Chemical Properties

CAS	84783-01-7
Formula	C11NOSH13
MW	207.292
Storage	4°C for 1 year, -20°C for more than 2 years

References

[1]. Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538. [2]. Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-6143

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