LC-2 Datasheet DC Chemicals

Description	LC-2 is a potent and first-in-class degrader of endogenous KRAS G12C with DC50 values between 0.25 and 0.76 μM. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines.
Cat.No	DC42435
Name	LC-2

Chemical Properties

CAS	2502156-03-6
Formula	C59H71CLFN11O7S
MW	1132.78
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

References

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