LIPID 14 is a novel ionizable lipid used for mRNA delivery.In 2021, Elia et al. used lipid 2 LNPs and lipid 14 LNPs to deliver mRNA encoding SARSCoV-2 human Fc-conjugated receptor binding domain (RBDhFc
mRNA). While both lipid 274 LNP RBD-hFc mRNA and
lipid 14 LNP RBD-hFc mRNA induced equal cellular and
humoral responses in mice at an mRNA dose of 5 μg, only lipid
14 LNP RBD-hFc mRNA exhibited strong immunogenicity
following intradermal administration. Both intradermal administration
and intramuscular administration of lipid 14 LNPs
could activate antigen presenting cells (APCs), thus inducing
cellular responses.
Cat.No
DC82125
Name
lipid 14
Chemical Properties
CAS
2430034-05-0
Formula
C56H110N2O6
MW
907.48
Storage
References
1 An Effective mRNA-LNP Vaccine Against the Lethal Plague Bacterium
Edo Kon,Dan Peer, Ofer Cohen-doi: biorxiv, https://doi.org/10.1101/2022.08.07.503096
2 Elia, U.; Ramishetti, S.; Rosenfeld, R.; Dammes, N.; Bar-Haim,
E.; Naidu, G. S.; Makdasi, E.; Yahalom-Ronen, Y.; Tamir, H.; Paran, N.;
et al. Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding
Domain mRNA Vaccine Delivered via Lipid Nanoparticles. ACS
Nano 2021
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