LOXO 195(Selitrectinib) Datasheet DC Chemicals

Description	LOXO-195 is a next-generation TRK kinase (TKI) inhibitor, with IC50s of 0.6±0.1 nM, <2.5 nM for TRKA and TRKC respectively.
Cat.No	DC11448
Name	LOXO 195(Selitrectinib)

Chemical Properties

CAS	2097002-61-2
Formula	C20H21FN6O
MW	380.4187
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7(9):963-972.

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