Pirtobrutinib (LOXO-305) Datasheet DC Chemicals

Description	LOXO-305 is an investigational, novel, selective non-covalent Bruton’s tyrosine kinase (BTK) inhibitor. LOXO-305 was designed to reversibly bind BTK, preserve activity in the presence of the acquired resistance, and avoid off-target kinases that have complicated the development of both covalent and investigational non-covalent BTK inhibitors.LOXO-305 is a highly selective, non-covalent BTKi that inhibits both wild type (WT) and C481-mutated BTK with equal low nM potency was developed.
Cat.No	DC50020
Name	Pirtobrutinib (LOXO-305)

Chemical Properties

CAS	2101700-15-4
Formula	C22H21F4N5O3
MW	479.427458524704
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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