LY 264618 Datasheet DC Chemicals
Description Lometrexol is a folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate.
Cat.No DC31344
Name LY 264618

Chemical Properties

CAS 120408-07-3
Formula C21H23N5NA2O6
MW 487.42
Storage

References

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