Lersivirine（UK 453061） Datasheet DC Chemicals
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Cat.No DC5052
Name Lersivirine（UK 453061）

Chemical Properties

CAS 473921-12-9
Formula C17H18N4O2
MW 310.35
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target: IC50 value: 0.119 uM [1] Target: NNRTI
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Mowbray CE, et al. Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5857-60. [2]. Davis J, et al. The effect of lersivirine, a next-generation NNRTI, on the pharmacokinetics of midazolam and oral contraceptives in healthy subjects. Eur J Clin Pharmacol. 2012 Nov;68(11):1567-72. [3]. Cappon GD, et al. Developmental toxicity study of lersivirine in mice. Birth Defects Res B Dev Reprod Toxicol. 2012 Jun;95(3):225-30.
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