Lometrexol hydrate Datasheet DC Chemicals

Description	Lometrexol hydrate (DDATHF hydrate), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.
Cat.No	DC41066
Name	Lometrexol hydrate

Chemical Properties

CAS	1435784-14-7
Formula	C21H27N5O7
MW	461.47
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

References

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