Lumacaftor(vx-809，vx809) Datasheet DC Chemicals

Description	VX-809 is a CFTR modulator with EC50 of 0.1 μM.
Cat.No	DC1059
Name	Lumacaftor(vx-809，vx809)

Chemical Properties

CAS	936727-05-8
Formula	C24H18F2N2O5
MW	452.41
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Van Goor F, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18843-8. [2]. Phuan PW, et al. Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul;86(1):42-51.

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