The study of the effect of Luteolin on the improvement of cancerous cachexia in model mice showed that luteolin can improve the symptoms of cancer cachexia model mice.The mechanism may be related to inhibition of proteasome and calcium activated protease activity and lower the levels of cytokines [3].
In Vitro
Luteolin exerted an anticancer effect against NCI-H460 cells through Sirt1-mediated apoptosis and the inhibition of cell migration [1]. The treatment of luteolin upregulated the expression levels of transforming growth factor β1 (TGF-β1), p21WAF1/CIP1, p27KIP1, Smad4, and Fas in HCC cells. Luteolin induced apoptotic cell death in Hep3B cells while caused G1 arrest in HepG2 cells. And it induces apoptosis from G1 arrest via three signaling pathways of TGF-β1, p53, and Fas/Fas-ligand in HCC cells [2]
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Liping Ma, et al. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis. Molecular MedicineReports, 2015, 12 (3): 4196-4202
[2]. Su Bog Yee, et al. Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway. International Journal of Oncology, 2015, 47 (2): 747-754
[3]. Pang Tao, et al. Effect of Luteolin on the Improvement of Cancerous Cachexia in Model Mice. China Pharmacy, 2015-07
[4]. Divyashree Ravishankar, et al. Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal ChemistryVolume 97, 5 June 2015, Pages 259–274
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