MB-07344 Datasheet DC Chemicals
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Cat.No DC60035
Name MB-07344

Chemical Properties

CAS 852947-39-8
Formula C19H25O5P
MW 364.378
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：852947-39-8
Product Name：((4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)phosphonic acid
Synonyms：R1ZW9H43ZJ;BDBM50242403;Phosphonic acid, p-((4-((4-hydroxy-3-(1-methylethyl)phenyl)methyl)-3,5-dimethylphenoxy)methyl)-;Q27287686;(3,5-dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy)methylphosphonicacid;((4-(4-Hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)phosphonic acid;[(4-{[4-hydroxy-3-(propan-2-yl)phenyl]methyl}-3,5-dimethylphenoxy)methyl]phosphonic acid;[3,5-Dimethyl-4-(4''-h;[4-[(4-hydroxy-3-propan-2-ylphenyl)methyl]-3,5-dimethylphenoxy]methylphosphonic acid;WXG00614;W19284;(
EINECS:
Molecular Formula：C19H25O5P
Molecular Weight：364.378
Target: Ki: 2.17 nM (Thyroid hormone receptor-β)[1]
In Vivo
In Vitro MB-07344 (0.05 mg/kg; given i.v., 3 times per week for 3 weeks) results in adjunctive and additive activity when given in combination with atorvastatin in normal rabbits[1]. Animal Model: Normal rabbits[1] Dosage: 0.05 mg/kg Administration: Given i.v., 3 times per week for 3 weeks Result: Combination with atorvastatin further reduced cholesterol.
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Ito BR, et al. Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys. Br J Pharmacol. 2009 Feb;156(3):454-65.
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