MK-7246 Datasheet DC Chemicals

Description	MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM.
Cat.No	DC10785
Name	MK-7246

Chemical Properties

CAS	1218918-62-7
Formula	C21H21FN2O4S
MW	416.12
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Gervais FG, et al. Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist. Mol Pharmacol. 2011 Jan;79(1):69-76. [2]. Gil MA, et al. Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation. Eur J Pharmacol. 2014 Nov 15;743:106-16.

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