MK-0557 Datasheet DC Chemicals
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Cat.No DC10045
Name MK-0557

Chemical Properties

CAS 328232-95-7
Formula C22H19FN4O3
MW 406.41
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:
In Vivo
In Vitro MK-0557 antagonizes the effects of the NPY5R-selective agonist on body-weight gain and hyperphagia in C57BL/6J mice and significantly suppresses the body-weight gain in diet-induced obese (DIO) mice. When lean mice on regular chow are switched to a medium high-fat diet (4.2 kcal/g) and treated with MK-0557 at 30 mg/kg PO QD, MK-0557 causes a 40% reduction inbody-weight gain at day 35[2].
Kinase Assay
Cell Assay
Animal Administration

References

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