MRT68921 Datasheet DC Chemicals
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Cat.No DC9702
Name MRT68921

Chemical Properties

CAS 1190379-70-4
Formula C27H38CL2N4O
MW 505.528
Storage 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Biological activity

Description
Target:
In Vivo
In Vitro ULK1, a serine/threonine protein kinase, is essential for the initial stages of autophagy. MRT68921 inhibits ULK1 and ULK2 in vitro and block autophagy in cells. MRT68921 is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nm) and greater than a 30-fold reduction for ULK2 (1.1 nm). Autophagy-inhibiting capacity of the compounds is specifically through ULK1. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation[1].
Kinase Assay
Cell Assay
Animal Administration

References

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