MitoNeoD is a novel mitochondria-targeted O2(??) probe that can be used in vivo. It prevents DNA intercalation. MitoNeoD incorporates a carbon-deuterium bond, and enhances O2(??) selectivity. MitoNeoD comprises a O2?--sensitive reduced phenanthridinium moiety modified to prevent DNA intercalation, as well as a carbon-deuterium bond to enhance its selectivity for O2?- over non-specific oxidation, and a triphenylphosphonium lipophilic cation moiety leading to the rapid accumulation within mitochondria. MitoNeoD is a versatile and robust probe to assess changes in mitochondrial O2?- from isolated mitochondria to animal models, thus offering a way to examine the many roles of mitochondrial O2?- production in health and disease.
Cat.No
DC34481
Name
MitoNeoD
Chemical Properties
CAS
Formula
C53H62DBRN3P
MW
853.9919
Storage
References
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