NLG919(GDC-0919) Datasheet DC Chemicals
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Cat.No DC5172
Name NLG919(GDC-0919)

Chemical Properties

CAS 1402836-58-1
Formula C18H22N2O
MW 282.38
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:
In Vivo
In Vitro IDO-IN-7 (NLG-919 analogue) is a potent IDO1 inhibitor (IC50=38 nM). The binding mode of IDO-IN-7 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme. IDO-IN-7 has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier[1].
Kinase Assay
Cell Assay
Animal Administration

References

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