NMS-P118 Datasheet DC Chemicals

Description	NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor with excellent ADME and pharmacokinetic profiles and high efficacy in vivo.
Cat.No	DC9936
Name	NMS-P118

Chemical Properties

CAS	1262417-51-5
Formula	C20H24F3N3O2
MW	395.43
Storage	4°C for 1 year, -20°C for more than 2 years

References

[1]. Papeo G, et al. Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. J Med Chem. 2015 Sep 10;58(17):6875-98.

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