Naspm Datasheet DC Chemicals
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Cat.No DC9341
Name Naspm

Chemical Properties

CAS 122306-11-0
Formula C22H35N4O
MW 371.54000
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：122306-11-0
Product Name：1-Naphthylacetylspermine
Synonyms：1-Naphthaleneacetamide,N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-;1-Naphthylacetyl spermine;NASPM TRIHYDROCHLORIDE;Naspm trihydrochloride,N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamidetrihydrochloride;N-[3-[[4-[(3-AMinopropyl)aMino]butyl]aMino]propyl]-1-naphthaleneacetaMidetrihydrochloride;Naspm;C13674;NASPM trihydrochloride;1-naphthylacetylspermine;N-[3-[4-(3-Aminopropylamino)butylamino]propyl]naphthalene-1-acetamide;N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide;2-(1-Naphtyl)-N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]acetamide;1-NA-Spm;N-[3-[4-(3-aminopropylamino)butylamino]propyl]-2-naphthalen-1-ylacetamide;N-[3-({4-[(3-AMINOPROPYL)AMINO]BUTYL}AMINO)PROPYL]-2-(NAPHTHALEN-1-YL)ACETAMIDE;1-Naphthaleneacetamide, N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-;1-Naphthaleneacetamide, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-;SCHEMB
EINEC:
Molecular Formula：C22H35N4O
Molecular Weight：371.54000
Target:
In Vivo
In Vitro NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.
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