ODM-203 Datasheet DC Chemicals
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Cat.No DC12445
Name ODM-203

Chemical Properties

CAS 1430723-35-5
Formula C26H21F2N5O2S
MW 505.544
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1430723-35-5
Product Name：N-(2',4'-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-3-yl)cyclopropanesulfonamide
Synonyms：ODM203;ODM 203
EINEC:
Molecular Formula：C26H21F2N5O2S
Molecular Weight：505.544
Target: FGFR1:11 nM (IC50) FGFR2:16 nM (IC50) FGFR3:6 nM (IC50) FGFR4:35 nM (IC50) VEGFR1:26 nM (IC50) VEGFR2:9 nM (IC50) VEGFR3:5 nM (IC50) DDR1:6 nM (IC50) RET:8 nM (IC50) SIK3:23 nM (IC50) PDGFRa:35 nM (IC50) MINK1:41 nM (IC50) MAP4K4:49 nM (IC50)
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Holmström TH, et al. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol Cancer Ther. 2019 Jan;18(1):28-38.
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