OICR9429 Datasheet DC Chemicals
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Cat.No DC9985
Name OICR9429

Chemical Properties

CAS 1801787-56-3
Formula C29H32F3N5O3
MW 555.59
Storage 4°C for 1 year, -20°C for more than 2 years

Biological activity

Description
Target:
In Vivo
In Vitro OICR-9429 inhibit proliferation and induce differentiation in p30-expressing human AML cells. OICR-9429 cause a significant decrease in viability in the majority of patient cells with mutations in the N-terminal part of the CEBPA gene. OICR-9429 displays exquisite cellular selectivity and specificity in disrupting critical protein-protein interactions between WDR5. [1] reduce the viability of primary human AML cells with N-terminal C/EBPα mutations by about 50% (mean value, n = 8) at 5 μM[2]In vivo:The reference for OICR-9429 to mice (female NOD-SCID) is 3 mg/kg.
Kinase Assay
Cell Assay
Animal Administration

References

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