PF-04447943 Datasheet DC Chemicals

Description	PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis.
Cat.No	DC11367
Name	PF-04447943

Chemical Properties

CAS	1082744-20-4
Formula	C20H25N7O2
MW	395.5
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Kleiman RJ, et al. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J Pharmacol Exp Ther. 2012 May;341(2):396-409. [2]. Hutson, P. H, et al.

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