PF-04418948 Datasheet DC Chemicals

Description	PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).
Cat.No	DC8353
Name	PF-04418948

Chemical Properties

CAS	1078166-57-0
Formula	C23H20FNO5
MW	409.41
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. af Forselles KJ, et al. In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist. Br J Pharmacol. 2011 Dec;164(7):1847-1856. [2]. Birrell MA, et al. Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor. Br J Pharmacol. 2013 Jan;168(1):129-138.

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