PF-5006739 Datasheet DC Chemicals
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Cat.No DC8146
Name PF-5006739

Chemical Properties

CAS 1293395-67-1
Formula C22H22FN7O
MW 419.454786777496
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1293395-67-1
Product Name：2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-
Synonyms：
EINEC:
Molecular Formula：C22H22FN7O
Molecular Weight：419.454786777496
Target: CK1δ:3.9 nM (IC50) CK1ϵ:17.0 nM (IC50)
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Wager TT, et al. Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem Neurosci. 2014 Dec 17;5(12):1253-65. [2]. Cunningham PS, et al. Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.Sci Rep. 2016 Jul 21;6:29983.
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