PHD-1-IN-1 Datasheet DC Chemicals
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Cat.No DC58150
Name PHD-1-IN-1

Chemical Properties

CAS 2009343-14-8
Formula C13H8N4
MW 220.2
Storage -20

Biological activity

Description CAS NO.：2009343-14-8
Product Name：PHD-1-IN-1
Synonyms：PHD-1-IN-1;PHD-1-IN-1
EINECS:
Molecular Formula：C13H8N4
Molecular Weight：220.2
Target: IC50: 0.034 μM (PHD-1)[1]
In Vivo PHD-1-IN-1 (compound 17; 3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng•h/mL, Kp,uu of 1.11 and B/P of 0.95[1]. Animal Model: Male C57BL6 mice[1] Dosage: 3 mg/kg (p.o.) or 0.5 mg/kg (i.v.) (Pharmacokinetic Analysis) Administration: PO or IV Result: Had a Cmax of 0.8 μM, a AUC of 176 ng•h/mL, Kp,uu of 1.11 and B/P of 0.95.
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017 Jul 13;60(13):5663-5672.
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