PLB-1001 Datasheet DC Chemicals
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Cat.No DC12462
Name PLB-1001

Chemical Properties

CAS 1440964-89-5
Formula C20H15F3N8
MW 424.391
Storage Please store the product under the recommended conditions in the Certificate of Analysis.

Biological activity

Description
Target:
In Vivo
In Vitro Bozitinib (PLB-1001) (30 μM; 6 hours) inhibits the phosphorylation of MET and STAT3, has a robust inhibitory effect of PLB-1001 on MET and its downstream signaling pathways. Western Blot Analysis[1] Cell Line: Human astrocytes (HA) cells Concentration: 30 μM Incubation Time: 6 hours Result: Decreased p-STAT3,p-MET expression.
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Hu H, et al. Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell. 2018 Nov 29;175(6):1665-1678.e18.
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