PLX7904(PB04) Datasheet DC Chemicals

Description	PLX7904(PB04) is a potent and selective paradox-breaker RAF inhibitor.
Cat.No	DC9814
Name	PLX7904(PB04)

Chemical Properties

CAS	1393465-84-3
Formula	C24H22F2N6O3S
MW	512.14
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Zhang C, et al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526(7574):583-586. [2]. Basile KJ, et al. Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors. Pigment Cell Melanoma Res. 2014 May;27(3):479-84 [3]. Le K, et al. Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells. Pigment Cell Melanoma Res. 2013 Jul;26(4):509-17

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