PQR620 Datasheet DC Chemicals

Description	PQR620 is a novel potent and selective brain penetrant inhibitor of mTORC1/2.
Cat.No	DC20221
Name	PQR620

Chemical Properties

CAS	1927857-56-4
Formula	C21H25F2N7O2
MW	445.47
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Florent Beaufils, et al. Abstract 1336: Structure-activity relationship studies, synthesis, and biological evaluation of PQR620, a highly potent and selective mTORC1/2 inhibitor. Cancer Research; 2016 Apr 16-20. [2]. Chiara Tarantelli, et al. Targeting the PI3K/mTOR Pathway in Lymphoma with PQR309 and PQR620: Single Agent Activity and Synergism with the BCL2 Inhibitor Venetoclax. Blood 2016 128:3017.

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