PRX-08066 Datasheet DC Chemicals

Description	PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that causes selective vasodilation of pulmonary arteries.
Cat.No	DC9979
Name	PRX-08066

Chemical Properties

CAS	866206-54-4
Formula	C19H17CLFN6S
MW	401.89
Storage	4°C for 1 year, -20°C for more than 2 years

References

[1]. Porvasnik SL, et al. PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. J Pharmacol Exp Ther. 2010 Aug;334(2):364-72. [2]. Svejda B, et al. The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. Cancer. 2010 Jun 15;116(12):2902-12. [3]. Warburton R.R., et al. Online University.

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