PSI6206 Datasheet DC Chemicals
Description PSI-6206 is a selective inhibitor of hepatitis C virus (HCV).
Cat.No DC6309
Name PSI6206

Chemical Properties

CAS 863329-66-2
Formula C10H13FN2O5
MW 260.22
Storage 2 years -20°C powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8. [2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29 [3]. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24.
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