PSI-6206 is a selective inhibitor of hepatitis C virus (HCV).
Cat.No
DC6309
Name
PSI6206
Chemical Properties
CAS
863329-66-2
Formula
C10H13FN2O5
MW
260.22
Storage
2 years -20°C powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
[1]. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8.
[2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29
[3]. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24.
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