PU-02 Datasheet DC Chemicals
Description PU-02 is a potent and selective 5-HT3 receptor antagonist. PU02 displays IC(50) values of ~1 μM at 5-HT(3)Rs and substantially lower activities at other Cys-loop receptors. In an elaborate mutagenesis study of the 5-HT(3)A receptor guided by a homology model, PU02 is demonstrated to act through a transmembrane intersubunit site situated in the upper three helical turns of TM2 and TM3 in the (+)-subunit and TM1 and TM2 in the (-)-subunit.
Cat.No DC33195
Name PU-02

Chemical Properties

CAS 313984-77-9
Formula C16H12N4S
MW 292.36
Storage

References

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