Pimelic Diphenylamide 106(TC-H 106) Datasheet DC Chemicals

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Cat.No	DC8661
Name	Pimelic Diphenylamide 106(TC-H 106)

Chemical Properties

CAS	937039-45-7
Formula	C20H25N3O2
MW	339.43
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:	HDAC1:150 nM (IC50) HDAC3:370 nM (IC50) HDAC2:760 nM (IC50) HDAC8:5000 nM (IC50)
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409. [2]. Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989.

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