Pyridoclax(MR29072) Datasheet DC Chemicals

Description	Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor with Kd value of 25 nM.
Cat.No	DC8128
Name	Pyridoclax(MR29072)

Chemical Properties

CAS	1651890-44-6
Formula	C29H22N4
MW	426.51
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Gloaguen C, et al. First evidence that oligopyridines, α-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. J Med Chem. 2015 Feb 26;58(4):1644-68. [2]. Groo AC, et al. Comparison of 2 strategies to enhance Pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis. Eur J Pharm Sci. 2017 Jan 15;97:218-226.

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